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What if Rimuru ended up in a universe were everyone's gender was the contrary from the original universe? If it is from the beginning or if because of spell he ended up there, is to your choice.
Of course that the names of some characters would or could change like Leon would Leonia, Benimaru as Benihime, Guy Crimson would probably be Gal Crimson(because it sounds better then Girl Crimson), Chloe would be something like Clover, etc.
About ships...it would be whichever the one writing prefers but I would like to see what they would come up with since most of Rimurus' simps would now be boys(Ciel may continue to be female if you wish but I do prefer her and Rimuru to have a platonic relationship but I do enjoy fics with them as a romantic one).
Would this changes affect the story? Maybe, it once again would depend on the writer but also if the characters would keep their core personalities or have small changes that could be attributed to the change of gender(sometimes when writing the genderbend of a character, they end up being softer if it is a male turned female or colder/harder if it is female turned male).
But, no matter how you decide to go, I wanna request to keep the scene were Guy/Gal bites/licks(I don't really remember what exactly he did) Rimuru's ear because the reaction to it may be even better with this changes.